K27M mutation of histone H3 has been identified as a driver event in diffuse midline glioma. Two studies used comprehensive multi-model single-cell genomic, epigenomic and chromatin structure analysis to characterize the cell of origin and find a distinct etiology of H3K27M between pontine and thalamic tumors, and show that pontine gliomas harbor more immature oligodendrocyte-precursor-like cells.
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Li, XN. Defining the cell of origin for diffuse midline gliomas. Nat Genet 54, 1770–1771 (2022). https://doi.org/10.1038/s41588-022-01231-8
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DOI: https://doi.org/10.1038/s41588-022-01231-8
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