Few genetic alterations have been linked to metastasis, during which cancer cells acquire abnormal migratory behavior. A new study sheds light on how loss of NECTIN1 leads to melanoma dissemination after local depletion of IGF1.
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Barcelo, J., Sanz-Moreno, V. NECTIN1 is a melanoma metastasis suppressor gene. Nat Genet 54, 1776–1777 (2022). https://doi.org/10.1038/s41588-022-01229-2
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DOI: https://doi.org/10.1038/s41588-022-01229-2
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