Adult human kidney organoids or tubuloids are derived from an epithelial CD24+ subpopulation in the proximal nephron and can be utilized for advanced disease modeling of the most common hereditary kidney disease: autosomal dominant polycystic kidney disease.
References
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This is a summary of: Xu, Y. et al. Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease. Nat. Genet. https://doi.org/10.1038/s41588-022-01202-z (2022).
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Adult human kidney organoids: cellular origin and disease modeling. Nat Genet 54, 1593–1594 (2022). https://doi.org/10.1038/s41588-022-01207-8
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DOI: https://doi.org/10.1038/s41588-022-01207-8
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