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RNA post-transcriptional modification speaks to chromatin

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The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease.

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Fig. 1: RNA modification and sequence context regulate gene expression at multiple levels.

References

  1. Lavi, U., Fernandez-Muñoz, R. & Darnell, J. E. Jr. Nucleic Acids Res. 4, 63–69 (1977).

    Article  CAS  Google Scholar 

  2. Fitzsimmons, C. M. & Batista, P. J. Biochim. Biophys. Acta. Gene Regul. Mech. 1862, 382–393 (2019).

    Article  CAS  Google Scholar 

  3. Bertero, A. et al. Nature 555, 256–259 (2018).

    Article  CAS  Google Scholar 

  4. Kuppers, D. A. et al. Nat. Commun. 10, 4596 (2019).

    Article  Google Scholar 

  5. Aguilo, F. et al. Cell Stem Cell 17, 689–704 (2015).

    Article  CAS  Google Scholar 

  6. Liu, J. et al. Science 367, 580–586 (2020).

    Article  CAS  Google Scholar 

  7. Huang, H. et al. Nature 567, 414–419 (2019).

    Article  CAS  Google Scholar 

  8. Slobodin, B. et al. Cell 169, 326–337.e12 (2017).

    Article  CAS  Google Scholar 

  9. Xiao, S. et al. Nat. Cell Biol. 21, 651–661 (2019).

    Article  CAS  Google Scholar 

  10. Li, Y. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0677-3 (2020).

  11. Zhang, Z. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0644-z (2020).

  12. Schwartz, S. et al. Cell Rep. 8, 284–296 (2014).

    Article  CAS  Google Scholar 

  13. Edupuganti, R. R. et al. Nat. Struct. Mol. Biol. 24, 870–878 (2017).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Dalen Chan & Pedro J. Batista

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  1. Dalen Chan
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  2. Pedro J. Batista
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Correspondence to Pedro J. Batista.

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The authors declare no competing interests.

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Chan, D., Batista, P.J. RNA post-transcriptional modification speaks to chromatin. Nat Genet 52, 868–869 (2020). https://doi.org/10.1038/s41588-020-0685-3

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