Binding of RNA to the gene expression regulator Polycomb repressive complex 2 (PRC2) has been proposed to antagonize PRC2’s chromatin recruitment. A new study now shows that RNA is in fact critical for correct recruitment of PRC2 at its target genes in human pluripotent stem cells and suggests that interplay of PRC2 and RNA can fine-tune PRC2’s regulatory role.
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References
Schuettengruber, B., Bourbon, H. M., Di Croce, L. & Cavalli, G. Cell 171, 34–57 (2017).
Laugesen, A., Hojfeldt, J. W. & Helin, K. Mol. Cell 74, 8–18 (2019).
Chammas, P., Mocavini, I. & Di Croce, L. Br. J. Cancer 122, 315–328 (2020).
Rinn, J. L. et al. Cell 129, 1311–1323 (2007).
Cifuentes-Rojas, C., Hernandez, A. J., Sarma, K. & Lee, J. T. Mol. Cell 55, 171–185 (2014).
Davidovich, C., Zheng, L., Goodrich, K. J. & Cech, T. R. Nat. Struct. Mol. Biol. 20, 1250–1257 (2013).
Zhang, Q. et al. Nat. Struct. Mol. Biol. 26, 237–247 (2019).
Long, Y. et al. Nat. Genet. https://doi.org/10.1038/s41588-020-0662-x (2020).
Beltran, M. et al. Nat. Struct. Mol. Biol. 26, 899–909 (2019).
Wang, X. et al. Nat. Struct. Mol. Biol. 24, 1028–1038 (2017).
Riising, E. M. et al. Mol. Cell 55, 347–360 (2014).
Mas, G. et al. Nat. Genet. 50, 1452–1462 (2018).
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Mocavini, I., Di Croce, L. RNA closing the Polycomb circle. Nat Genet 52, 866–867 (2020). https://doi.org/10.1038/s41588-020-0683-5
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DOI: https://doi.org/10.1038/s41588-020-0683-5
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