TET2 and DNMT3A mutations lead to similar long-term outcomes in blood cancers despite the antagonistic biochemical functions of their encoded proteins. A new study highlights the opposing effects of TET2 and DNMT3A mutations in shaping the early erythroid or myeloid bias of hematopoietic progenitors.
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López-Moyado, I.F., Rao, A. DNMT3A and TET2 mutations reshape hematopoiesis in opposing ways. Nat Genet 52, 554–556 (2020). https://doi.org/10.1038/s41588-020-0641-2
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DOI: https://doi.org/10.1038/s41588-020-0641-2
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