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HUMAN DISEASE

Expanding the genetic basis of ataxia

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More than one dozen hereditary ataxias are caused by repeat expansions. A newly discovered expansion may be the first known common genetic cause of late-onset ataxia.

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Fig. 1: A new repeat expansion linked to late-onset cerebellar ataxia.

References

  1. Paulson, H. L., Shakkottai, V. G., Clark, H. B. & Orr, H. T. Nat. Rev. Neurosci. 18, 613–626 (2017).

    Article  CAS  Google Scholar 

  2. Cook, A. & Giunti, P. Br. Med. Bull. 124, 19–30 (2017).

    Article  CAS  Google Scholar 

  3. Paulson, H. Handb. Clin. Neurol. 147, 105–123 (2018).

    Article  Google Scholar 

  4. Hannan, A. J. Nat. Rev. Genet. 19, 286–298 (2018).

    Article  CAS  Google Scholar 

  5. Cortese, A. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0372-4 (2019).

    Article  CAS  Google Scholar 

  6. Synofzik, M. & Németh, A. H. Handb. Clin. Neurol. 155, 73–89 (2018).

    Article  Google Scholar 

  7. Mundwiler, A. & Shakkottai, V. G. Handb. Clin. Neurol. 147, 173–185 (2018).

    Article  Google Scholar 

  8. Szmulewicz, D. J. et al. Neurol. Clin. Pract. 6, 61–68 (2016).

    Article  Google Scholar 

  9. Yoon, G. & Caldecott, K. W. Handb. Clin. Neurol. 155, 105–115 (2018).

    Article  Google Scholar 

  10. Shiomi, Y. & Nishitani, H. Genes (Basel) 8, E52 (2017).

    Article  Google Scholar 

  11. Zhang, N. & Ashizawa, T. Curr. Opin. Genet. Dev. 44, 17–29 (2017).

    Article  CAS  Google Scholar 

  12. Madireddy, A. & Gerhardt, J. Adv. Exp. Med. Biol. 1042, 549–581 (2017).

    Article  CAS  Google Scholar 

  13. Balendra, R. & Isaacs, A. M. Nat. Rev. Neurol. 14, 544–558 (2018).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Neurology, University of Michigan, Ann Arbor, MI, USA

    Vikram Shakkottai & Henry Paulson

Authors
  1. Vikram Shakkottai
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  2. Henry Paulson
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Correspondence to Vikram Shakkottai or Henry Paulson.

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The authors declare no competing interests.

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Shakkottai, V., Paulson, H. Expanding the genetic basis of ataxia. Nat Genet 51, 580–581 (2019). https://doi.org/10.1038/s41588-019-0387-x

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