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HUMAN GENETICS

Resolving variant-to-function relationships in hematopoiesis

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Resolving variant-to-function relationships is a key challenge faced by human geneticists. A new study combining statistical fine-mapping with cell-type-specific functional annotations advances the understanding of the regulatory consequences of genetic variants associated with variations in blood-cell traits.

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Fig. 1: Switch versus tune mechanism for genetic variants.

References

  1. Ulirsch, J. C. et al. Nat. Genet. https://doi.org/10.1038/s41588-019-0362-6 (2019).

    Article  CAS  Google Scholar 

  2. Astle, W. J. et al. Cell 167, 1415–1429.e19 (2016).

    Article  CAS  Google Scholar 

  3. Benner, C. et al. Am. J. Hum. Genet. 101, 539–551 (2017).

    Article  CAS  Google Scholar 

  4. Mendelson, A. & Frenette, P. S. Nat. Med. 20, 833–846 (2014).

    Article  CAS  Google Scholar 

  5. Wei, Q. & Frenette, P. S. Immunity 48, 632–648 (2018).

    Article  CAS  Google Scholar 

  6. Warr, M. R., Pietras, E. M. & Passegué, E. Wiley Interdiscip. Rev. Syst. Biol. Med. 3, 681–701 (2011).

    Article  CAS  Google Scholar 

  7. Manesso, E., Teles, J., Bryder, D. & Peterson, C. J. R. Soc. Interface 10, 20120817 (2013).

    Article  Google Scholar 

  8. Ramond, C. et al. Development 145, dev165480 (2018).

    Article  Google Scholar 

  9. Loh, P. R. et al. Nature 559, 350–355 (2018).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Human Genetics, Wellcome Sanger Institute, Hinxton, UK

    Manuel Tardaguila & Nicole Soranzo

  2. Department of Haematology, University of Cambridge, Cambridge, UK

    Nicole Soranzo

Authors
  1. Manuel Tardaguila
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  2. Nicole Soranzo
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Correspondence to Nicole Soranzo.

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The authors declare no competing interests.

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Tardaguila, M., Soranzo, N. Resolving variant-to-function relationships in hematopoiesis. Nat Genet 51, 581–583 (2019). https://doi.org/10.1038/s41588-019-0386-y

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