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Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

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Fig. 1: A simple branching-process model of tumor evolution.
Fig. 2: An infinite-allele branching-process model of tumor evolution, including sampling as in the original study.
Fig. 3: The model from the original study for multiple simulations.

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Acknowledgements

The authors would like to acknowledge discussions with members of the Michor laboratory and with N. Navin, D. Pellman and K. Polyak. This work was supported by the Dana-Farber Cancer Institute Physical Sciences Oncology Center (NCI U54CA193461).

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Author notes

  1. These authors contributed equally: Thomas O. McDonald, Shaon Chakrabarti.

Authors and Affiliations

  1. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA

    Thomas O. McDonald, Shaon Chakrabarti & Franziska Michor

  2. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA

    Thomas O. McDonald, Shaon Chakrabarti & Franziska Michor

  3. Center for Cancer Evolution, Dana-Farber Cancer Institute, Boston, MA, USA

    Thomas O. McDonald & Franziska Michor

  4. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA

    Thomas O. McDonald, Shaon Chakrabarti & Franziska Michor

Authors
  1. Thomas O. McDonald
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  2. Shaon Chakrabarti
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  3. Franziska Michor
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Contributions

T.O.M. and S.C. developed the models, performed simulations and analyzed results. F.M. conceived the idea. All authors wrote the manuscript.

Corresponding author

Correspondence to Franziska Michor.

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The authors declare no competing interests.

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McDonald, T.O., Chakrabarti, S. & Michor, F. Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution. Nat Genet 50, 1620–1623 (2018). https://doi.org/10.1038/s41588-018-0217-6

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