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DISEASE GENETICS

Genetic risks and clinical rewards

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Individual genome-wide polygenic risk scores (GPSs) for assessing disease susceptibility have been shown to yield both reliable and clinically meaningful results. However, certain impediments and outdated ways of thinking about health maintenance must be overcome before GPSs are adopted in routine care streams.

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Fig. 1: Example conditional risk probabilites assuming two diseases are of interest.

References

  1. Khera, A. V. et al. Nat. Genet. https://doi.org/10.1038/s41588-018-0183-z (2018).

  2. Torkamani, A., Wineinger, N. E. & Topol, E. J. Nat. Rev. Genet. https://doi.org/10.1038/s41576-018-0018-x (2018).

  3. Marigorta, U. M., Rodríguez, J. A., Gibson, G. & Navarro, A. Trends Genet. 34, 504–517 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Martin, A. R. et al. Am. J. Hum. Genet. 100, 635–649 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Yang, Q. et al. Am. J. Hum. Genet. 85, 786–800 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Desikan, R. S. et al. PLoS Med. 14, e1002258 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Patel, C. J. et al. Genome Med. 5, 58 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Schork, N. J. Genome Med. 5, 54 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Bloss, C. S., Schork, N. J. & Topol, E. J. N. Engl. J. Med. 364, 524–534 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Helgesson, G. J. Law Med. Ethics 42, 28–37 (2014).

    Article  PubMed  Google Scholar 

  11. Nguyen, T. N. et al. Am. Health Drug Benefits 9, 475–485 (2016).

    PubMed  PubMed Central  Google Scholar 

  12. Brainstorm Consortium et al. Science 360, eaap8757 (2018).

  13. Wang, Y. et al. Mult. Scler. 22, 1783–1793 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Yokoyama, J. S. et al. JAMA Neurol. 73, 691–697 (2016).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Schork, N. J. & Topol, E. J. J. Biopharm. Stat. 20, 315–333 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Nicholas J. Schork.

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Schork, A.J., Schork, M.A. & Schork, N.J. Genetic risks and clinical rewards. Nat Genet 50, 1210–1211 (2018). https://doi.org/10.1038/s41588-018-0213-x

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