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Mapping regulatory variants in hiPSC models

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A new study illustrates the power of the human induced pluripotent stem cell (hiPSC) platform by studying hiPSC-derived sensory neurons from 107 individuals. In addition to identifying thousands of quantitative trait loci influencing gene expression, chromatin accessibility and RNA splicing, the work highlights several underappreciated challenges in the hiPSC field.

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Fig. 1: hiPSC-based studies of disease risk depend on the retention of a donor-specific component of gene expression.

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Authors and Affiliations

  1. Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Gabriel E. Hoffman & Kristen J. Brennand

  2. Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Gabriel E. Hoffman & Kristen J. Brennand

  3. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Kristen J. Brennand

  4. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Kristen J. Brennand

  5. Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Kristen J. Brennand

Authors
  1. Gabriel E. Hoffman
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  2. Kristen J. Brennand
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Corresponding authors

Correspondence to Gabriel E. Hoffman or Kristen J. Brennand.

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The authors declare no competing financial interests.

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Hoffman, G.E., Brennand, K.J. Mapping regulatory variants in hiPSC models. Nat Genet 50, 1–2 (2018). https://doi.org/10.1038/s41588-017-0017-4

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