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Tracing the fate of AAV vectors in the body

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A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.

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Fig. 1: Analysis of AAV genomes and transgene expression in the non-human primate liver.

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Author information

Authors and Affiliations

  1. Grousbeck Gene Therapy Center, Schepens Eye Research Institute, Mass Eye and Ear, Boston, MA, USA

    Nerea Zabaleta

  2. Noscendo GmbH, Duisburg, Germany

    Irene Gil-Farina

Authors
  1. Nerea Zabaleta
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  2. Irene Gil-Farina
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Corresponding author

Correspondence to Irene Gil-Farina.

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Competing interests

N.Z. declares no competing interests. I.G.F. was an employee of a contract research organization offering vector integration services.

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Zabaleta, N., Gil-Farina, I. Tracing the fate of AAV vectors in the body. Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02047-5

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  • DOI: https://doi.org/10.1038/s41587-023-02047-5

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