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Applied immunology

Antibiotic nanoparticles boost antitumor immunity

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Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T cell immunity.

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Fig. 1: Antibiotics-loaded liposomes kill intratumoral bacteria and elicit antitumor T cell immunity.

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Author notes

  1. These authors contributed equally: Kai Han, Young Seok Cho.

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA

    Kai Han, Young Seok Cho & James J. Moon

  2. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China

    Kai Han

  3. Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA

    Kai Han, Young Seok Cho & James J. Moon

  4. Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA

    James J. Moon

Authors
  1. Kai Han
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  2. Young Seok Cho
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  3. James J. Moon
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Corresponding author

Correspondence to James J. Moon.

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Competing interests

J.J.M. declares financial interests for board membership, as a paid consultant, for research funding, and/or as an equity holder in EVOQ Therapeutics and Saros Therapeutics.

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Han, K., Cho, Y.S. & Moon, J.J. Antibiotic nanoparticles boost antitumor immunity. Nat Biotechnol (2023). https://doi.org/10.1038/s41587-023-02046-6

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  • DOI: https://doi.org/10.1038/s41587-023-02046-6

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