The protracted timeline of maturation is a major bottleneck in generating adult-like neurons from human pluripotent stem cells. We identify a combination of four chemicals that promotes neuronal maturation by repressing epigenetic factors that inhibit it and stimulating activity-dependent factors that promote it.
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This is a summary of: Hergenreder, E. et al. Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-02031-z (2024).
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Identification of a chemical cocktail that drives the maturation of human neurons. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-023-02044-8
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DOI: https://doi.org/10.1038/s41587-023-02044-8
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