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Imaging glycosylated RNAs at the subcellular scale

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A recently discovered RNA species on the cell surface is studied by proximity ligation.

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Fig. 1: Neu5Ac-binding aptamer meets an RNA sequence-specific binding probe to detect sialoglycoRNA in situ.

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Authors and Affiliations

  1. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA

    Petar Hristov

  2. Stem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA, USA

    Petar Hristov & Ryan A. Flynn

  3. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA

    Ryan A. Flynn

  4. Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

    Ryan A. Flynn

Authors
  1. Petar Hristov
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  2. Ryan A. Flynn
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Correspondence to Ryan A. Flynn.

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The authors declare no competing interests.

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Hristov, P., Flynn, R.A. Imaging glycosylated RNAs at the subcellular scale. Nat Biotechnol 42, 574–575 (2024). https://doi.org/10.1038/s41587-023-02021-1

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