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Applied immunology

Hypoimmune cells resist rejection in monkeys

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Genetic engineering to block immune destruction of transplanted cells succeeds in macaques.

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Fig. 1: Cellular engineering to generate hypoimmune cells.

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Authors and Affiliations

  1. Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Asuncion Borrero Borrego & Saar Gill

  2. Salamanca Biomedical Institute (IBSAL), University of Salamanca, Salamanca, Spain

    Asuncion Borrero Borrego

  3. Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, Philadelphia, PA, USA

    Saar Gill

  4. Cellular Therapy and Transplantation, Abramson Cancer Center of the University of Pennsylvania, Philadelphia, PA, USA

    Saar Gill

Authors
  1. Asuncion Borrero Borrego
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  2. Saar Gill
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Correspondence to Saar Gill.

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The authors declare no competing interests.

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Borrero Borrego, A., Gill, S. Hypoimmune cells resist rejection in monkeys. Nat Biotechnol 42, 380–382 (2024). https://doi.org/10.1038/s41587-023-02013-1

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