Skip to main content
Log in

Protein engineering

Perfecting antibodies with language models

  • News & Views
  • Published:

From Nature Biotechnology

View current issue Submit your manuscript

A general-purpose protein language model rapidly improves antibody properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Directed evolution with language models.

References

  1. Hie, B. L. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01763-2 (2023).

    Article  PubMed  Google Scholar 

  2. Smith, G. P. Science 228, 1315–1317 (1985).

  3. Arnold, F. Angew. Chem. Int. Edn Engl. 58, 14420–14426 (2019).

  4. Ferruz, N. et al. Nat. Machin. Intell. 4, 521–532 (2022).

  5. Rives, A. et al. Proc. Natl Acad. Sci. USA 118, e2016239118 (2021).

  6. Meier, J. et al. Adv. Neural Inf. Process. Syst. 34, 29287–29303 (2021).

  7. Olsen, T. H. et al. Bioinform. Adv. 2, vbac046 (2022).

  8. Prihoda, D. et al. MAbs 14, 2020203 (2022).

  9. Fowler, D. M. et al. Nat. Methods 11, 801–807 (2014).

  10. Outeiral, C. & Deane, C. M. Preprint at bioRxiv https://doi.org/10.1101/2022.12.15.519894 (2022).

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Charlotte M. Deane.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Outeiral, C., Deane, C.M. Perfecting antibodies with language models. Nat Biotechnol 42, 185–186 (2024). https://doi.org/10.1038/s41587-023-01991-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41587-023-01991-6

  • Springer Nature America, Inc.

Navigation