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Framework for multiplicative scaling of single-cell proteomics

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Many biomedical questions demand scalable, deep, and accurate proteome analysis of small samples, including single cells. A scalable framework of multiplexed data-independent acquisition for mass spectrometry enables time saving by parallel analysis of both peptide ions and protein samples, thereby realizing multiplicative gains in throughput.

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Fig. 1: Increasing the throughput and accuracy of sensitive proteomics.

References

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This is a summary of: Derks, J. et al. Increasing the throughput of sensitive proteomics by plexDIA. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01389-w (2021).

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Framework for multiplicative scaling of single-cell proteomics. Nat Biotechnol 41, 23–24 (2023). https://doi.org/10.1038/s41587-022-01411-1

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