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Rescuing imperfect antigens for immuno-oncology

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Targeting two antigens with BiTE-secreting CAR-T cells limits tumor immune escape in glioblastoma.

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Fig. 1: CART-BiTE cells target two antigens, EGFRvIII and wt EGFR, on GBM tumor cells.

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Authors and Affiliations

  1. Department of Immunology, Duke University Graduate School, Durham, NC, USA

    Selena J. Lorrey & Peter E. Fecci

  2. Brain Tumor Immunotherapy Program, Duke University Medical Center, Durham, NC, USA

    Selena J. Lorrey, Luis Sanchez-Perez & Peter E. Fecci

  3. Department of Neurosurgery, Duke University School of Medicine, Durham, NC, USA

    Luis Sanchez-Perez & Peter E. Fecci

Authors
  1. Selena J. Lorrey
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  2. Luis Sanchez-Perez
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  3. Peter E. Fecci
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Correspondence to Peter E. Fecci.

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Lorrey, S.J., Sanchez-Perez, L. & Fecci, P.E. Rescuing imperfect antigens for immuno-oncology. Nat Biotechnol 37, 1002–1003 (2019). https://doi.org/10.1038/s41587-019-0248-2

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