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Doubling down on siRNAs in the brain

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Divalent siRNAs induce widespread gene silencing in the brains of mice and non-human primates.

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Fig. 1: Chemical and viral-based methods for inducing gene silencing.

References

  1. Stiles, D. K. et al. Exp. Neurol. 233, 463–471 (2012).

    Article  CAS  Google Scholar 

  2. Kordasiewicz, H. B. et al. Neuron 74, 1031–1044 (2012).

    Article  CAS  Google Scholar 

  3. Harper, S. Q. et al. Proc. Natl Acad. Sci. USA 102, 5820–5825 (2005).

    Article  CAS  Google Scholar 

  4. Boudreau, R. L. et al. J. Am. Soc. Gene Therapy 17, 1053–1063 (2009).

    Article  CAS  Google Scholar 

  5. Miniarikova, J., Evers, M. M. & Konstantinova, P. Mol. Therapy 26, 947–962 (2018).

    Article  CAS  Google Scholar 

  6. Tabrizi, S. J. et al. N. Engl. J. Med. 380, 2307–2316 (2019).

    Article  CAS  Google Scholar 

  7. Alterman, J. F. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0205-0 (2019).

  8. Hassler, M. R. et al. Nucleic Acids Res. 46, 2185–2196 (2018).

    Article  CAS  Google Scholar 

  9. Bartel, D. P. Cell 173, 20–51 (2018).

    Article  CAS  Google Scholar 

  10. The Huntington’s Disease Collaborative Research Group. Cell 72, 971–983 (1993).

    Article  Google Scholar 

  11. DiFiglia, M. et al. Proc. Natl Acad. Sci. USA 104, 17204–17209 (2007).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. The Raymond G. Perelman Center for Cellular and Molecular Therapeutics, the Children’s Hospital of Philadelphia, and the Department of Pathology and Laboratory Medicine, The University of Pennsylvania, Philadelphia, PA, USA

    Beverly L. Davidson

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  1. Beverly L. Davidson
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Correspondence to Beverly L. Davidson.

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Competing interests

B.L.D. is a founder of Spark Therapeutics, Inc and Talee Bio, and is on the scientific advisory boards of Homology Medicines, Prevail Therapeutics, Sarepta Therapeutics and Panorama Medicines.

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Davidson, B.L. Doubling down on siRNAs in the brain. Nat Biotechnol 37, 865–866 (2019). https://doi.org/10.1038/s41587-019-0204-1

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