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Sexual medicine

Doxycycline-PEP — novel and promising but needs monitoring

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Sexually transmitted infections (STIs) remain public health concerns. Doxycycline post-exposure prophylaxis to prevent STIs is a novel promising intervention, which in a new study caused an ∼65% reduction in incident STIs. However, long-term effects on STI prevalence, microbiomes and antimicrobial resistance among STI pathogens, non-STI pathogens and commensals need to be monitored.

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Acknowledgements

Work at the WHO Collaborating Centre for Gonorrhoea and Other STIs is supported by grants to M.U. from, for example, the Örebro County Council Research Committee; the Foundation for Medical Research at Örebro University Hospital, Örebro, Sweden; the Global Antibiotic Research and Development Partnership (GARDP); the European Centre for Disease Prevention and Control; and WHO. F.Y.S.K. is supported by a University of Melbourne Faculty C.R. Roper Fellowship.

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Authors and Affiliations

  1. WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden

    Magnus Unemo

  2. Institute for Global Health, University College London, London, UK

    Magnus Unemo

  3. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia

    Fabian Yuh Shiong Kong

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  1. Magnus Unemo
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  2. Fabian Yuh Shiong Kong
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Correspondence to Magnus Unemo.

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The authors declare no competing interests.

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Unemo, M., Kong, F.Y.S. Doxycycline-PEP — novel and promising but needs monitoring. Nat Rev Urol 20, 522–523 (2023). https://doi.org/10.1038/s41585-023-00788-1

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