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AR variants: lost in translation to clinical practice?

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The concept that resistance against androgen receptor (AR) signalling inhibitors is explained by AR variants (ARVs) has spread as a seductive meme. However, two problems have delayed the translation of these findings to clinical practice: the complexity of the mechanism of action and the challenging development of clinical decision-making tools involving ARVs.

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Fig. 1: ARVs in prostate cancer.

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Authors and Affiliations

  1. Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium

    Florian Handle & Frank Claessens

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  1. Florian Handle
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  2. Frank Claessens
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Correspondence to Frank Claessens.

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The authors declare no competing interests.

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Handle, F., Claessens, F. AR variants: lost in translation to clinical practice?. Nat Rev Urol 16, 451–452 (2019). https://doi.org/10.1038/s41585-019-0204-4

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