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Enzalutamide, apalutamide, or darolutamide: are apples or bananas best for patients?

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The PROSPER, SPARTAN, and ARAMIS trials demonstrated the efficacy of enzalutamide, apalutamide, and darolutamide, respectively, to extend metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer. However, questions remain regarding patient selection for these agents, particularly concerning adverse effects, patient PSA doubling time, and cost and formulary considerations.

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Fig. 1: Considerations when choosing a second-generation antiandrogen.

References

  1. Hussain, M. et al. Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. N. Engl. J. Med. 378, 2465–2474 (2018).

    Article  CAS  Google Scholar 

  2. Smith, M. R. et al. Apalutamide treatment and metastasis-free survival in prostate cancer. N. Engl. J. Med. 378, 1408–1418 (2018).

    Article  CAS  Google Scholar 

  3. Fizazi, K. et al. Darolutamide in nonmetastatic, castration-resistant prostate cancer. N. Engl. J. Med. 380, 1235–1246 (2019).

    Article  CAS  Google Scholar 

  4. Moilanen, A. M. et al. Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. Sci. Rep. 5, 12007 (2015).

    Article  Google Scholar 

  5. Scher, H. I. et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase1-2 study. Lancet 375, 1437–1446 (2010).

    Article  CAS  Google Scholar 

  6. Slovin, S. et al. Seizure rates in enzalutamide-treated men with metastatic castration-resistant prostate cancer and risk of seizure: the UPWARD study. JAMA Oncol. 24, 702–706 (2018).

    Article  Google Scholar 

  7. Ruiz Garcia, P. et al. Meta-analysis of randomized clinical trials in metastatic castration resistant prostate cancer: comparison of hypertension, neurological and psychiatric adverse events on enzalutamide and abiraterone acetate plus prednisone treatment [abstract]. Ann. Oncol. 27 (Suppl. 6), 738P (2016).

    Google Scholar 

  8. Smith, M. R. et al. Denosumab and bone metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer: exploratory analyses by baseline prostate-specific antigen doubling time. J. Clin. Oncol. 31, 3800–3806 (2013).

    Article  Google Scholar 

  9. Tombal, B. F. et al. Adverse events of special interest assessed by review of safety data in enzalutamide castration-resistant prostate cancer (CRPC) trials [abstract]. J. Clin. Oncol. 37 (Suppl. 7), 237 (2019).

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Oncology, Department of Medicine, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Celestia Higano

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  1. Celestia Higano
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Correspondence to Celestia Higano.

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Competing interests

The author declares that she has acted as a consultant for Bayer, Blue Earth Diagnostics, Clovis, Ferring, Hinova, and Janssen and has conducted research for Aragon, Astellas, AstraZeneca, Bayer, Emergent BioSolutions, Hoffman LaRoche, Medivation, and Pfizer.

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Higano, C. Enzalutamide, apalutamide, or darolutamide: are apples or bananas best for patients?. Nat Rev Urol 16, 335–336 (2019). https://doi.org/10.1038/s41585-019-0186-2

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