Re-establishing tolerance to autoantigens is an important aim for the treatment of rheumatoid arthritis (RA). Immunization of HLA-DR4 transgenic mice with citrullinated self-antigens can induce immune tolerance, which suggests that such antigens could have a therapeutic role in anti-citrullinated peptide antibody-positive RA.
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R.T. reports issued patent 9,017,697 B2: 2006 surrounding technology for targeting dendritic cells for antigen-specific tolerance, and funding from CSL to UniQuest to develop antigen-specific immunotherapy in Sjögren syndrome. W.H.R. declares no competing interests.
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Thomas, R., Robinson, W.H. Immune tolerance of citrullinated peptides. Nat Rev Rheumatol 20, 141–142 (2024). https://doi.org/10.1038/s41584-024-01081-0
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DOI: https://doi.org/10.1038/s41584-024-01081-0
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