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Proposals for the rheumatological use of JAK inhibitors

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An Author Correction to this article was published on 02 April 2024

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Janus kinase inhibitors have therapeutic potential for patients with immune-mediated inflammatory diseases, and evidence of greater risks of cardiovascular disease and malignancy than with TNF inhibitors should be carefully considered before recommendations against their use are made. Assessment of the risk–benefit ratios in these patients can instead guide clinical decision-making.

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Fig. 1: Proposed clinical approach to minimize risk for the use of JAK inhibitors in patients with rheumatoid arthritis, psoriatic arthritis or axial spondyloarthritis.

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Correspondence to Francesco Ciccia.

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Ciccia, F., Caporali, R. Proposals for the rheumatological use of JAK inhibitors. Nat Rev Rheumatol 20, 65–66 (2024). https://doi.org/10.1038/s41584-023-01068-3

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