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Systemic lupus erythematosus

Shifting the SLE management paradigm: challenges and implications

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From Nature Reviews Rheumatology

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Newly published European guidelines for the management of systemic lupus erythematosus (SLE) and lupus nephritis, specifically recommending early and aggressive use of new medications, signal that the old paradigm of SLE management is shifting. Although it presents challenges, this shift is welcome — and is likely to have far-reaching implications.

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Fig. 1: The paradigm shift in SLE management.

References

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Acknowledgements

K.H.C. is supported by the US National Institutes of Health (NIH K24 AR066109).

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Authors and Affiliations

  1. Division of Clinical Immunology and Allergy, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

    Jacob J. E. Koopman

  2. Division of Rheumatology, Inflammation and Immunity, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Jacob J. E. Koopman & Karen H. Costenbader

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  1. Jacob J. E. Koopman
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  2. Karen H. Costenbader
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Correspondence to Jacob J. E. Koopman.

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Competing interests

K.H.C. declares that she has received grants and/or research support from Amgen, AstraZeneca Exagen Diagnostics, Gilead, GlaxoSmithKline, and Janssen and has acted as a consultant for Amgen, Bristol-Myers Squibb, Cabaletta Bio, Eli Lilly, GlaxoSmithKlein and Janssen. J.J.E.K. declares no competing interests.

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Koopman, J.J.E., Costenbader, K.H. Shifting the SLE management paradigm: challenges and implications. Nat Rev Rheumatol 20, 5–6 (2024). https://doi.org/10.1038/s41584-023-01058-5

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