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Rheumatoid arthritis

Fibroblast multiplicity in RA: a synovial state of affairs

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Rheumatoid arthritis synovium contains phenotypically and functionally heterogeneous fibroblast-like synoviocytes. Cutting-edge analyses have now defined at least four distinct states of these cells related to their location in the synovium, epigenetic imprinting and the influence of microenvironment mediators.

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Fig. 1: Fibroblast states in the rheumatoid arthritis synovium.

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Authors and Affiliations

  1. Department of Medicine, UC San Diego School of Medicine, La Jolla, CA, USA

    Camilla R. L. Machado & Gary S. Firestein

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  1. Camilla R. L. Machado
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  2. Gary S. Firestein
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Correspondence to Gary S. Firestein.

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Competing interests

G.S.F. declares that he has received a research grant from Eli Lilly. C.R.L.M. declares no competing interests.

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Machado, C.R.L., Firestein, G.S. Fibroblast multiplicity in RA: a synovial state of affairs. Nat Rev Rheumatol 19, 609–610 (2023). https://doi.org/10.1038/s41584-023-01015-2

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