The phenotypic and functional heterogeneity of synovial tissue fibroblasts are well described, whereas the cellular and molecular mechanisms that establish this diverse fibroblast repertoire in the adult joint have remained unclear. When is the fate of synovial fibroblast repertoire determined, and what are the consequences for arthritis development as adults?
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A.P.C. is supported by the Kennedy Trust for Rheumatology Research and A.H. is supported by Versus Arthritis.
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Hackland, A., Croft, A.P. Are the origins of adult arthritis seeded during embryonic development?. Nat Rev Rheumatol 19, 132–133 (2023). https://doi.org/10.1038/s41584-023-00911-x
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DOI: https://doi.org/10.1038/s41584-023-00911-x
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