An important question for patients and providers is whether and to what extent dietary interventions, diet supplements or weight loss can help to prevent incident gout or manage existing gout. Evidence is emerging, but randomized trials are still needed to fill this important knowledge gap.
References
Singh, J. A., Shah, N. & Edwards, N. L. A cross-sectional internet-based patient survey of the management strategies for gout. BMC Complement. Altern. Med. 16, 90 (2016).
Juraschek, S. P. et al. Effects of dietary patterns on serum urate: results from the DASH randomized trial. Arthritis Rheumatol. https://doi.org/10.1002/art.41614 (2020).
Appel, L. J. et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N. Engl. J. Med. 336, 1117–1124 (1997).
Jacobs, D. R. Jr. & Steffen, L. M. Nutrients, foods, and dietary patterns as exposures in research: a framework for food synergy. Am. J. Clin. Nutr. 78, 508s–513s (2003).
Juraschek, S. P. et al. Effects of the Dietary Approaches to Stop Hypertension (DASH) diet and sodium intake on serum uric acid. Arthritis Rheumatol. 68, 3002–3009 (2016).
Li, C., Hsieh, M. C. & Chang, S. J. Metabolic syndrome, diabetes, and hyperuricemia. Curr. Opin. Rheumatol. 25, 210–216 (2013).
Stamp, L. K. et al. Clinically insignificant effect of supplemental vitamin C on serum urate in patients with gout: a pilot randomized controlled trial. Arthritis Rheum. 65, 1636–1642 (2013).
Stamp, L. K. et al. Lack of effect of tart cherry concentrate dose on serum urate in people with gout. Rheumatology 59, 2374–2380 (2020).
Singh, J. A. et al. A randomized internet-based pilot feasibility and planning study of cherry extract and diet modification in gout. J. Clin. Rheumatol. 26, 147–156 (2019).
Rai, S. K. et al. The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout in men: prospective cohort study. BMJ 357, j1794 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.A.S. has received consultant fees from the ACR, Adept Field Solutions, Clearview Healthcare Partners, Clinical Care Options, Crealta/Horizon, Fidia, Focus Forward, Medisys, Medscape, Navigant Consulting, the National Institutes of Health, Practice Point Communications, Putnam Associates, Spherix, Trio health, UBM LLC and WebMD. J.A.S. owns stock options in Charlotte’s Web Holdings, Inc., TPT Global Tech and Vaxart Pharmaceuticals. J.A.S. previously owned stock options in Amarin, Moderna Pharmaceuticals and Viking. J.A.S. is on the speaker’s bureau of Simply Speaking. J.A.S. is a member of the executive of Outcomes Measures in Rheumatology (OMERACT), an organization that receives arms-length funding from 12 companies. S.L.M. declares no competing interests.
Rights and permissions
About this article
Cite this article
Morgan, S.L., Singh, J.A. How do dietary interventions affect serum urate and gout?. Nat Rev Rheumatol 17, 191–192 (2021). https://doi.org/10.1038/s41584-021-00576-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41584-021-00576-4
- Springer Nature Limited