The European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and European Academy of Neurology (EAN) joint consensus statement on vaccination in people with multiple sclerosis provides highly relevant clinical guidance on immunization strategies in today’s era of effective immunotherapies. Nevertheless, several open questions remain to be addressed.
References
Otero-Romero, S. et al. ECTRIMS/EAN consensus on vaccination in people with multiple sclerosis: improving immunization strategies in the era of highly active immunotherapeutic drugs. Mult. Scler. https://doi.org/10.1177/13524585231168043 (2023).
Farez, M. F. et al. Practice guideline update summary: vaccine-preventable infections and immunization in multiple sclerosis: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology 93, 584–594 (2019).
Winkelmann, A., Loebermann, M., Barnett, M., Hartung, H.-P. & Zettl, U. K. Vaccination and immunotherapies in neuroimmunological diseases. Nat. Rev. Neurol. 18, 289–306 (2022).
Kaufmann, S. H. E. in Vaccination — Basics, Effects, Risks 11–12 (C. H. Beck, 2021).
Rommer, P. S. et al. Immunological aspects of approved MS therapeutics. Front. Immunol. 10, 1564 (2019).
Manouchehrinia, A., Tanasescu, R., Tench, C. R. & Constantinescu, C. S. Mortality in multiple sclerosis: meta-analysis of standardised mortality ratios. J. Neurol. Neurosurg. Psychiatry 87, 324–331 (2016).
Apostolidis, S. A. et al. Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy. Nat. Med. 27, 1990–2001 (2021).
Silva, P. B. R. & Silva, G. D. Risk and characteristics of attacks occurring after vaccination in patients with neuromyelitis optica spectrum disorders: a systematic review and meta-analysis. Mult. Scler. Relat. Disord. 75, 104741 (2023).
Krienke, C. et al. A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis. Science 371, 145–153 (2021).
Löbermann, M. et al. [Multiple sclerosis and hepatitis B vaccination : What does the verdict of the European Court of Justice on liability after vaccination mean?]. Nervenarzt 89, 1172–1178 (2018).
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Zettl, U.K., Rommer, P.S. New consensus guidelines on vaccination in multiple sclerosis. Nat Rev Neurol 19, 509–510 (2023). https://doi.org/10.1038/s41582-023-00854-7
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DOI: https://doi.org/10.1038/s41582-023-00854-7
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