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Multiple sclerosis

Inverse association between age and inflammatory disease activity in multiple sclerosis

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Two studies have confirmed previous observations that an inverse relationship exists between chronological age and focal white-matter inflammatory activity in individuals with multiple sclerosis, which could underlie the relative ineffectiveness of traditional disease-modifying therapies in older individuals.

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Authors and Affiliations

  1. Department of Neurology, The Ohio State University, Columbus, OH, USA

    Benjamin M. Segal

  2. Neuroscience Research Institute, The Ohio State University, Columbus, OH, USA

    Benjamin M. Segal

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  1. Benjamin M. Segal
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Correspondence to Benjamin M. Segal.

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Segal, B.M. Inverse association between age and inflammatory disease activity in multiple sclerosis. Nat Rev Neurol 19, 577–578 (2023). https://doi.org/10.1038/s41582-023-00844-9

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