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Dementia

Multisite chronic pain: a risk factor for dementia

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A study of more than 350,000 individuals has shown that multisite chronic pain is strongly correlated with elevated risk of dementia, decreased cognitive function and reduced hippocampal volume. Further study of these relationships and their potential underlying mechanisms is required and could inform the development of interventions to prevent or slow dementia.

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References

  1. Whitlock, E. L. et al. Association between persistent pain and memory decline and dementia in a longitudinal cohort of elders. JAMA Intern. Med. 177, 1146–1153 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Caraceni, A. & Shkodra, M. Cancer pain assessment and classification. Cancers (Basel) 11, 510 (2019).

    Article  PubMed  Google Scholar 

  3. Innes, K. E. & Sambamoorthi, U. The potential contribution of chronic pain and common chronic pain conditions to subsequent cognitive decline, new onset cognitive impairment, and incident dementia: a systematic review and conceptual model for future research. J. Alzheimers Dis. 78, 1177–1195 (2020).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Zhao, W., Zhao, L., Chang, X., Lu, X. & Tu, Y. Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain. Proc. Natl Acad. Sci. USA 120, e2215192120 (2023).

    Article  CAS  PubMed  Google Scholar 

  5. Cohen, S. P., Vase, L. & Hooten, W. M. Chronic pain: an update on burden, best practices, and new advances. Lancet 397, 2082–2097 (2021).

    Article  PubMed  Google Scholar 

  6. Mogil, J. S. Qualitative sex differences in pain processing: emerging evidence of a biased literature. Nat. Rev. Neurosci. 21, 353–365 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. Guerreiro, S. R. et al. Chronic pain causes Tau-mediated hippocampal pathology and memory deficits. Mol. Psychiatry 27, 4385–4393 (2022).

    Article  CAS  PubMed  Google Scholar 

  8. Cao, S., Fisher, D. W., Yu, T. & Dong, H. The link between chronic pain and Alzheimer’s disease. J. Neuroinflammation 16, 204 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  9. van Kooten, J. et al. A review of pain prevalence in Alzheimer’s, vascular, frontotemporal and Lewy body dementias. Dement. Geriatr. Cogn. Disord. 41, 220–232 (2016).

    Article  PubMed  Google Scholar 

  10. Atee, M., Morris, T., Macfarlane, S. & Cunningham, C. Pain in dementia: prevalence and association with neuropsychiatric behaviors. J. Pain Symptom Manage. 61, 1215–1226 (2021).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Hongxin Dong

  2. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Hongxin Dong

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  1. Hongxin Dong
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Correspondence to Hongxin Dong.

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The authors declare no competing interests.

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Dong, H. Multisite chronic pain: a risk factor for dementia. Nat Rev Neurol 19, 331–332 (2023). https://doi.org/10.1038/s41582-023-00807-0

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  • DOI: https://doi.org/10.1038/s41582-023-00807-0

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