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Migraine

Zavegepant for the acute treatment of migraine: look before leaping

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The armamentarium of acute medications for migraine is set to expand further with the results of a phase III trial, in which intranasal administration of zavegepant was superior to placebo in treating a single migraine attack. The therapeutic benefits were modest, however, and so more work is needed to address unmet treatment needs.

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Authors and Affiliations

  1. Harvard Medical School, Boston, MA, USA

    Håkan Ashina

  2. Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Håkan Ashina

  3. Department of Neurology, Danish Headache Center, Copenhagen University Hospital–Rigshospitalet, Copenhagen, Denmark

    Håkan Ashina & Peer Tfelt-Hansen

  4. Department of Brain and Spinal Cord Injury, Copenhagen University Hospital–Rigshospitalet, Copenhagen, Denmark

    Håkan Ashina

  5. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Håkan Ashina

Authors
  1. Håkan Ashina
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  2. Peer Tfelt-Hansen
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Corresponding author

Correspondence to Håkan Ashina.

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Competing interests

H.A. reports personal fees from Teva, outside of the submitted work. P.T.-H. declares no competing interests.

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Ashina, H., Tfelt-Hansen, P. Zavegepant for the acute treatment of migraine: look before leaping. Nat Rev Neurol 19, 329–330 (2023). https://doi.org/10.1038/s41582-023-00803-4

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