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PARKINSON DISEASE

Apomorphine infusion in advanced Parkinson disease

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The TOLEDO study provides new evidence to support the use of subcutaneous apomorphine infusion to control motor fluctuations in patients with advanced Parkinson disease. The findings should encourage neurologists to consider implementing apomorphine infusion or other device-aided therapies earlier in the disease course, before the emergence of troublesome dyskinesias.

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Fig. 1: Parkinson disease progression and therapy.

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Acknowledgements

The authors thank SciMentum, San Francisco, CA, USA for their help with drawing the figure.

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Authors and Affiliations

  1. Department of Neuroscience, University of Padua, Padua, Italy

    Angelo Antonini

  2. Neurodegenerative Diseases Research Group, Institute of Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King’s College, London, UK

    Peter Jenner

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  1. Angelo Antonini
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  2. Peter Jenner
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Correspondence to Angelo Antonini.

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The authors declare no competing interests.

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Antonini, A., Jenner, P. Apomorphine infusion in advanced Parkinson disease. Nat Rev Neurol 14, 693–694 (2018). https://doi.org/10.1038/s41582-018-0083-y

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