Human ageing trajectories are highly individual and dependent on genetic and non-genetic factors. An analysis of the interconnectivity of distinct age-related chronic diseases shows that organ-specific chronic diseases accelerate the ageing of other organ systems, which has important implications for mortality. Notably, chronic kidney disease was identified a highly important risk factor for the ageing of other organ systems.
References
Ferrucci, L. et al. Measuring biological aging in humans: a quest. Aging Cell 19, e13080 (2020).
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194–1217 (2013).
Tian, Y. E. et al. Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality. Nat. Med. https://doi.org/10.1038/s41591-023-02296-6 (2023).
Benzing, T. & Salant, D. Insights into glomerular filtration and albuminuria. N. Engl. J. Med. 384, 1437–1446 (2021).
Hallan, S. I. et al. Age and association of kidney measures with mortality and end-stage renal disease. J. Am. Med. Assoc. 308, 2349–2360 (2012).
Fontana, L. & Partridge, L. Promoting health and longevity through diet: from model organisms to humans. Cell 161, 106–118 (2015).
Horvath, S. DNA methylation age of human tissues and cell types. Genome Biol. 14, R115 (2013).
Zhu, T., Zheng, S. C., Paul, D. S., Horvath, S. & Teschendorff, A. E. Cell and tissue type independent age-associated DNA methylation changes are not rare but common. Aging 10, 3541–3557 (2018).
Belsky, D. W. et al. Quantification of biological aging in young adults. Proc. Natl Acad. Sci. USA 112, E4104–E4110 (2015).
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. Hallmarks of aging: an expanding universe. Cell 186, 243–278 (2023).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Benzing, T., Schumacher, B. Chronic kidney disease promotes ageing in a multiorgan disease network. Nat Rev Nephrol 19, 542–543 (2023). https://doi.org/10.1038/s41581-023-00729-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41581-023-00729-6
- Springer Nature Limited