The importance of incorporating factors related to sex and gender in all aspects of research is increasingly recognized. Kidney disease pathophysiology, presentation, response to therapy and outcomes differ by sex and gender, but these factors are often not considered in basic and clinical studies. It is time for nephrology to catch up.
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References
Sugimoto, C. R., Ahn, Y. Y., Smith, E., Macaluso, B. & Larivière, V. Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis. Lancet 393, 550–559 (2019).
Chang, D. H., Dumanski, S. M. & Ahmed, S. B. Female sex-specific considerations to improve rigor and reproducibility in cardiovascular research. Am. J. Physiol. Heart Circ. Physiol. 324, H279–H287 (2023).
Kwekel, J. C., Desai, V. G., Moland, C. L., Vijay, V. & Fuscoe, J. C. Sex differences in kidney gene expression during the life cycle of F344 rats. Biol. Sex Differ. 4, 14 (2013).
Bairey Merz, C. N. et al. Sex and the kidneys: current understanding and research opportunities. Nat. Rev. Nephrol. 15, 776–783 (2019).
US General Accounting Office. Drug Safety: Most Drugs Withdrawn in Recent Years Had Greater Health Risks for Women. https://www.gao.gov/assets/gao-01-286r.pdf (2001).
Vinson, A. J., Collister, D., Ahmed, S. & Tennankore, K. Underrepresentation of women in recent landmark kidney trials: the gender gap prevails. Kidney Int. Rep. 7, 2526–2529 (2022).
Collister, D. et al. Sex and gender in randomized controlled trials of adults receiving maintenance dialysis: a meta-epidemiologic study. Am. J. Kidney Dis. https://doi.org/10.1053/j.ajkd.2022.10.015 (2022).
Logie, C. H., van der Merwe, L. L. A. & Scheim, A. Measuring sex, gender, and sexual orientation: one step to health equity. Lancet 400, 715–717 (2022).
Rytz, C. L. et al. Improving the inclusion of transgender and nonbinary individuals in the planning, completion, and mobilization of cardiovascular research. Am. J. Physiol. Heart Circ. Physiol. 324, H366–H372 (2023).
Tannenbaum, C., Norris, C. M. & McMurtry, M. S. Sex-specific considerations in guidelines generation and application. Can. J. Cardiol. 35, 598–605 (2019).
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Ahmed, S.B. The importance of sex and gender in basic and clinical research. Nat Rev Nephrol 20, 2–3 (2024). https://doi.org/10.1038/s41581-023-00716-x
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DOI: https://doi.org/10.1038/s41581-023-00716-x
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