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Using the exposome to address gene–environment interactions in kidney disease

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From Nature Reviews Nephrology

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New exposome-based approaches permit omic-scale characterization of the non-genetic contributors to kidney disease. High-resolution mass spectrometry analysis of plasma and urine samples captures a wide range of exogenous and endogenous metabolites that can be used in combination with genetic risk factors to identify new biomarkers of exposure and therapeutic approaches.

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Authors and Affiliations

  1. College of Pharmacy, University of Arizona, Tucson, AZ, USA

    Tess V. Dupre & Rick G. Schnellmann

  2. Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA

    Gary W. Miller

Authors
  1. Tess V. Dupre
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  2. Rick G. Schnellmann
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  3. Gary W. Miller
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Correspondence to Gary W. Miller.

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The authors declare no competing interests.

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Dupre, T.V., Schnellmann, R.G. & Miller, G.W. Using the exposome to address gene–environment interactions in kidney disease. Nat Rev Nephrol 16, 621–622 (2020). https://doi.org/10.1038/s41581-020-0302-9

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  • DOI: https://doi.org/10.1038/s41581-020-0302-9

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