A recent study reports the first high-resolution, cryo-electron microscopy-based structure of zebrafish Na+-K+-Cl− cotransporter 1 (NKCC1). This structure provides important insights into the determinants of ion translocation by NKCC1 and other cation-Cl− cotransporters such as NKCC2. It could thus facilitate the design of drugs to target these transporters individually.
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The authors’ work is funded by the Canadian Institutes of Health Research and the Kidney Foundation of Canada.
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Garneau, A.P., Isenring, P. The structure of Na+-K+-Cl− cotransporter 1. Nat Rev Nephrol 15, 732–734 (2019). https://doi.org/10.1038/s41581-019-0204-x
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DOI: https://doi.org/10.1038/s41581-019-0204-x
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