Three reports from the TRACERx Renal study delineate the precise origin and evolution of clear cell renal cell carcinoma in minute detail. The insights gained from these studies might provide improved disease prognostics and identify novel therapeutic targets.
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References
Mitchell, T. J. et al. Timing the landmark events in the evolution of clear cell renal cell cancer: TRACERx Renal. Cell 173, 611–623.e17 (2018).
Turajlic, S. et al. Tracking cancer evolution reveals constrained routes to metastases: TRACERx Renal. Cell 173, 581–594.e12 (2018).
Turajlic, S. et al. Deterministic evolutionary trajectories influence primary tumor growth: TRACERx Renal. Cell 173, 595–610 e11 (2018).
Zbar, B. et al. Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327, 721–724 (1987).
Latif, F. et al. Identification of the von Hippel–Lindau disease tumor suppressor gene. Science 260, 1317–1320 (1993).
Fei, S. S. et al. Patient-specific factors influence somatic variation patterns in von Hippel-Lindau disease renal tumours. Nat. Commun. 7, 11588 (2016).
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 499, 43–49 (2013).
Gerlinger, M. et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N. Engl. J. Med. 366, 883–892 (2012).
Gerlinger, M. et al. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat. Genet. 46, 225–233 (2014).
Pena-Llopis, S. et al. BAP1 loss defines a new class of renal cell carcinoma. Nat. Genet. 44, 751–759 (2012).
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The authors’ work is supported by the Intramural Research Program of the US National Institutes of Health (NIH), National Cancer Institute, Center for Cancer Research.
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Ricketts, C.J., Linehan, W.M. The origin, evolution and route to metastasis of clear cell RCC. Nat Rev Nephrol 14, 538–540 (2018). https://doi.org/10.1038/s41581-018-0031-5
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DOI: https://doi.org/10.1038/s41581-018-0031-5
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