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CYSTIC KIDNEY DISEASE

Is ciliary Hedgehog signalling dispensable in the kidneys?

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An unbiased functional gene knockout screen to identify genes implicated in Hedgehog signalling in primary cilia detected most components of the ciliary machinery and ciliopathy-associated genes, but no kidney-related ciliopathy genes. The 472 hits are a tremendous resource for identifying potential ciliopathy genes and for analysing ciliary function and signalling pathways.

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Fig. 1: Directing of Cas9 by a guide RNA in the CRISPR–Cas9 system.

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Correspondence to Edgar A. Otto.

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Otto, E.A. Is ciliary Hedgehog signalling dispensable in the kidneys?. Nat Rev Nephrol 14, 415–416 (2018). https://doi.org/10.1038/s41581-018-0014-6

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