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Is endocytosis by caveolae dependent on dynamin?

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The large GTPase dynamin has a crucial role in endocytosis, working at the neck of clathrin-coated pits to drive vesicular scission. Until recently, dynamin was believed to regulate endocytosis through caveolae in a similar fashion. However, recent work calls for a serious reassessment of the role of dynamin in endocytosis by caveolae.

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Fig. 1: Comparison of the proposed roles of dynamin in clathrin-coated pits and caveolae.

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Acknowledgements

R.G.P. is funded by an ARC Laureate Fellowship. We thank S. Schmid for excellent discussions. J.W.T. is supported by the Intramural Research Program of the National Heart, Lung, and Blood Institute, National Institutes of Health, USA.

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Authors and Affiliations

  1. Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia

    Robert G. Parton

  2. Centre for Microscopy and Microanalysis, The University of Queensland, Brisbane, Queensland, Australia

    Robert G. Parton

  3. Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA

    Justin W. Taraska

  4. Medical and Translational Biology, Umeå University, Umeå, Sweden

    Richard Lundmark

  5. Molecular Infection Medicine Sweden, Umeå University, Umeå, Sweden

    Richard Lundmark

Authors
  1. Robert G. Parton
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  2. Justin W. Taraska
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  3. Richard Lundmark
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Correspondence to Robert G. Parton, Justin W. Taraska or Richard Lundmark.

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The authors declare no competing interests.

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Nature Reviews Molecular Cell Biology thanks Aurelien Roux for his contribution to the peer review of this work.

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Parton, R.G., Taraska, J.W. & Lundmark, R. Is endocytosis by caveolae dependent on dynamin?. Nat Rev Mol Cell Biol (2024). https://doi.org/10.1038/s41580-024-00735-x

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  • DOI: https://doi.org/10.1038/s41580-024-00735-x

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