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Extracellular vesicles: a new communication paradigm?

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Biological information can be shared between cells via extracellular vesicles. However, how cargo carried by extracellular vesicles elicits biological responses remains unresolved. Deciphering the molecular mechanisms that govern packaging and targeted delivery of extracellular vesicle cargo will be required to establish extracellular vesicles as important signalling entities.

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References

  1. van Niel, G., D’Angelo, G. & Raposo, G. Shedding light on the cell biology of extracellular vesicles. Nat. Rev. Mol. Cell Biol. 19, 213–228 (2018).

    Article  PubMed  Google Scholar 

  2. Jeppesen, D. K. et al. Reassessment of exosome composition. Cell 177, 428–445 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Stahl, P. D. & Raposo, G. Extracellular vesicles: exosomes and microvesicles, Integrators of homeostasis. Physiology (Bethesda) 34, 169–177 (2019).

    CAS  Google Scholar 

  4. Chevillet, J. R. et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc. Natl Acad. Sci. USA 111, 14888–14893 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Shapiro, J. A. No genome is an island: toward a 21st century agenda for evolution. Ann. NY Acad. Sci. https://doi.org/10.1111/nyas.14044 (2019).

    Article  PubMed  Google Scholar 

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Acknowledgements

The authors are grateful to members of the International Society for Extracellular Vesicles and all their colleagues for fruitful insights and for stimulating discussions. The authors thank the Fondation pour la Recherche Médicale (FRM), The Ligue National Contre le Cancer, Institut Curie and the Centre National de la Recherche Scientifique (CNRS) for support. This commentary is dedicated to the memory of our colleague Rose Johnstone for her pioneering studies.

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Authors and Affiliations

  1. Institut Curie, Paris Sciences et Lettres Research University, Centre National de la Recherche Scientifique UMR144, Structure and Membrane Compartments, Paris, France

    Graça Raposo

  2. Department of Cell Biology, Washington University School of Medicine, St Louis, MO, USA

    Philip D. Stahl

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  1. Graça Raposo
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  2. Philip D. Stahl
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Correspondence to Graça Raposo or Philip D. Stahl.

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Raposo, G., Stahl, P.D. Extracellular vesicles: a new communication paradigm?. Nat Rev Mol Cell Biol 20, 509–510 (2019). https://doi.org/10.1038/s41580-019-0158-7

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