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Decelerating ageing and biological clocks by autophagy

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Ageing is the most important risk factor for the majority of human pathologies. We propose the concept that the advancement of the hallmarks of ageing is dictated by several distinct biological clocks that can be decelerated by the induction of autophagy. This ‘time dilation’ delays the time-dependent manifestation of multiple diseases.

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References

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Authors and Affiliations

  1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Oviedo, Spain

    Carlos Lopez-Otín

  2. Equipe labellisée par la Ligue contre le cancer, Université Paris Descartes, Université Sorbonne Paris Cité, Université Paris Diderot, Sorbonne Université, INSERM U1138, Centre de Recherche des Cordeliers, Paris, France

    Carlos Lopez-Otín & Guido Kroemer

  3. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France

    Guido Kroemer

  4. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France

    Guido Kroemer

  5. Suzhou Institute for Systems Biology, Chinese Academy of Sciences, Suzhou, China

    Guido Kroemer

  6. Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden

    Guido Kroemer

Authors
  1. Carlos Lopez-Otín
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  2. Guido Kroemer
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Corresponding author

Correspondence to Guido Kroemer.

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Competing interests

G.K. is a scientific cofounder for Samsara Therapeutics. The other author declares no conflict of interest.

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Lopez-Otín, C., Kroemer, G. Decelerating ageing and biological clocks by autophagy. Nat Rev Mol Cell Biol 20, 385–386 (2019). https://doi.org/10.1038/s41580-019-0149-8

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  • DOI: https://doi.org/10.1038/s41580-019-0149-8

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