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Are tolerance and training required to end TB?

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Host defence strategies against Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), include host resistance and disease tolerance. To date, most studies have focused on resistance mechanisms, but developing new strategies to eradicate Mtb will require an understanding of the entire landscape of immunity in TB. Here I discuss two evolutionarily conserved host defence strategies, disease tolerance and trained immunity (memory-like innate immune responses), and their role in Mtb infection.

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Fig. 1: Nuts and bolts of trained immunity.

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Acknowledgements

This work was supported by the Canadian Institute of Health Research (CIHR) Foundation Grant (FDN-143273) to M.D. and M.D. holds a Fonds de la Recherche du Quebec- Sante (FRQS) Award and the Strauss Chair in Respiratory Diseases.

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Authors and Affiliations

  1. Departments of Medicine, Microbiology and Immunology, and Pathology, Meakins-Christie Laboratories, McGill International TB Centre and McGill University Health Centre, McGill University, Montreal, Québec, Canada

    Maziar Divangahi

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  1. Maziar Divangahi
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Correspondence to Maziar Divangahi.

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The author declares no competing interests.

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Divangahi, M. Are tolerance and training required to end TB?. Nat Rev Immunol 18, 661–663 (2018). https://doi.org/10.1038/s41577-018-0070-y

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