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Stem cells

Stem cell-derived organoid models: defying the Hayflick limit

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From Nature Reviews Genetics

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References

Original article

  • Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585–621 (1961)

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Related article

  • Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262–265 (2009)

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Max Planck Institute of Molecular Cell Biology and Genetics, Center for Systems Biology Dresden and Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany

    Meritxell Huch

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  1. Meritxell Huch
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Correspondence to Meritxell Huch.

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Competing interests

M.H. is listed as co-inventor on several patents related to organoid technology.

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Huch, M. Stem cell-derived organoid models: defying the Hayflick limit. Nat Rev Genet 24, 348 (2023). https://doi.org/10.1038/s41576-023-00577-x

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  • DOI: https://doi.org/10.1038/s41576-023-00577-x

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