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Ribosomal protein genes as sensors of aneuploidy

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During development, cell competition causes apoptosis of cells with abnormal ribosomal protein profiles. Ji et al. show that this same mechanism also deletes aneuploid cells and that the deleted cell populations mainly have altered ribosomal protein gene dosages.

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References

Original article

  • Ji, Z. et al. Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose. eLife 10, e61172 (2021)

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  1. Nature Reviews Genetics http://www.nature.com/nrg/

    Caroline Barranco

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  1. Caroline Barranco
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Correspondence to Caroline Barranco.

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Barranco, C. Ribosomal protein genes as sensors of aneuploidy. Nat Rev Genet 22, 414 (2021). https://doi.org/10.1038/s41576-021-00373-5

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  • DOI: https://doi.org/10.1038/s41576-021-00373-5

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