Magnetic resonance imaging following injection of hepatobiliary contrast agents improves the detection of hepatocellular carcinomas when contrast agent accumulations in tumours and the surrounding pathological liver differ. However, tissue accumulation is poorly investigated, and this Clinical Outlook article highlights experimental data to understand better contrast agent accumulation in human pathological livers.
This is a preview of subscription content, log in via an institution to check access.
References
Vilgrain, V., Van Beers, B. E. & Pastor, C. M. Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI. J. Hepatol. 64, 708–716 (2016).
Narita, M. et al. Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma. J. Gastroenterol. 44, 793–798 (2009).
Sourbron, S. A tracer-kinetic field theory for medical imaging. IEEE Trans. Med. Imaging 33, 935–946 (2014).
Pastor, C. M. & Brouwer, K. L. R. New pharmacokinetic parameters of imaging substrates quantified from rat liver compartments. Drug Metab. Dispos. 50, 58–64 (2022).
Pastor, C. M. & Vilgrain, V. Steatosis alters the activity of hepatocyte membrane transporters in obese rats. Cells 10, 2733 (2021).
Taniguchi, T. et al. Interindividual diversity in expression of organic anion uptake transporters in normal and cirrhotic human liver. Hepatol. Commun. 4, 739–752 (2020).
Vildhede, A., Kimoto, E., Pelis, R. M., Rodrigues, A. D. & Varma, M. V. S. Quantitative proteomics and mechanistic modeling of transporter-mediated disposition in nonalcoholic fatty liver disease. Clin. Pharmacol. Ther. 107, 1128–1137 (2020).
Hardwick, R. N., Fisher, C. D., Canet, M. J., Scheffer, G. L. & Cherrington, N. J. Variations in ATP-binding cassette transporter regulation during the progression of human nonalcoholic fatty liver disease. Drug Metab. Dispos. 39, 2395–2402 (2011).
Leporq, B. et al. Quantification of hepatic perfusion and hepatocyte function with dynamic gadoxetic acid-enhanced MRI in patients with chronic liver disease. Clin. Sci. 132, 813–824 (2018).
Bastati, N. et al. Noninvasive differentiation of simple steatosis and steatohepatitis by using gadoxetic acid-enhanced MR imaging in patients with nonalcoholic fatty liver disease: a proof-of-concept study. Radiology 271, 739–747 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Additional information
Related links
Rights and permissions
About this article
Cite this article
Pastor, C.M., Vilgrain, V. New understanding of hepatobiliary MRI. Nat Rev Gastroenterol Hepatol (2024). https://doi.org/10.1038/s41575-024-00926-z
Published:
DOI: https://doi.org/10.1038/s41575-024-00926-z
- Springer Nature Limited