Data based on next-generation sequencing (NGS) of colorectal cancers (CRC) clearly show that up to 10% of all cases harbour pathogenic variants. Thus, NGS performed for all patients with CRC under the age of 50 could be a cost-effective strategy, leading to a personalized approach to patients and family members.
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Acknowledgements
The authors’ work was funded by the Italian Foundation for Cancer Research (AIRC) under Investigator Grant N. 21723 (to L.R.) and Investigator Grant N. 22234 (to L.L.).
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Laghi, L., Ricciardiello, L. The changing approach for identifying hereditary colorectal cancer syndromes. Nat Rev Gastroenterol Hepatol 17, 593–594 (2020). https://doi.org/10.1038/s41575-020-0348-y
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DOI: https://doi.org/10.1038/s41575-020-0348-y
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