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Reproductive endocrinology

A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions

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Over the past decade, the focus on modelling the human endometrium and its cyclical transformations has intensified, driven in part by the lack of notable progress in treating endometrial diseases. Gnecco and collaborators now unveil a cutting-edge endometrial organoid culture using synthetic hydrogels with endometrial niche peptides and epithelial and stromal cells.

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Fig. 1: Endometrial organoids in an engineered extracellular matrix.

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Authors and Affiliations

  1. Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA

    J. Julie Kim

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  1. J. Julie Kim
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Correspondence to J. Julie Kim.

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The author declares no competing interests.

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Kim, J.J. A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions. Nat Rev Endocrinol 20, 3–4 (2024). https://doi.org/10.1038/s41574-023-00917-1

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