Immune checkpoint inhibitor therapies induce potent anti-tumour immunity as well as immune-related adverse events that manifest as autoimmune disease — particularly thyroiditis. Translational studies and preclinical models are beginning to unravel the molecular processes that mediate these adverse events; this knowledge might enable the development of ICIs with anti-tumour efficacy and improved safety margins.
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Lechner, M.G., Ryder, M. Insights into immune checkpoint inhibitor-induced thyroiditis. Nat Rev Endocrinol 17, 643–644 (2021). https://doi.org/10.1038/s41574-021-00557-3
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DOI: https://doi.org/10.1038/s41574-021-00557-3
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